Exploiting Long Non-Coding RNAs and Circular RNAs as Pharmacological Targets in Triple-Negative Breast Cancer Treatment

Breast cancer is one of the most frequent causes death among women worldwide. In particular, triple-negative breast (TNBC) represents aggressive subtype because it characterized by absence molecular targets, thus making an orphan type malignancy. The discovery new druggable targets mandatory to improve treatment success. that context, non-coding RNAs represent opportunity for modulation cancer. They are RNA molecules with apparently no protein coding potential, which have been already demonstrated play pivotal roles within cells, being involved in different processes, such as proliferation, cell cycle regulation, apoptosis, migration, and diseases, including Accordingly, they could be used future TNBC personalized therapy. Moreover, peculiar characteristics make them reliable biomarkers monitor treatment, thus, recurrence or chemoresistance, challenging aspects TNBC. present review, we focused on oncogenic oncosuppressor role long (lncRNAs) circular (circRNAs) mostly TNBC, highlighting their mode action depicting potential a biomarker and/or RNA-based therapeutics.